The Allentown-bound truck was cut off by another vehicle on Rt. 22 at St. James Avenue just before 12:50 p.m. in Pohatcong, local police said.
The other vehicle collided with the truck and caused the truck to swerve off the road. The truck went off Rt. 22 and onto St. James Avenue where it crashed into three other cars and rolled over onto its side.
A total of six people were transported to the hospital for multiple different injuries, all non-life-threatening.
James Avenue near the Phillipsburg Easton Honda remains closed during cleanup. Rt. 22 west in down to two travel lanes.
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